Alpha‐synuclein RT‐QuIC in the CSF of patients with alpha‐synucleinopathies
نویسندگان
چکیده
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.
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BRIEF COMMUNICATION Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies Graham Fairfoul, Lynne I. McGuire, Suvankar Pal, James W. Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G. Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T. M. Hu, Laura Parkkinen & Alison J. E. Green The National CJD Research & Surveillance Un...
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